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Cal y ne Home About Services Evidence Summary Safety Considerations Research Roadmap Contact Evidence, uncertainty, and safety Cocaine And Ibogaine: What Is Actually Known Ibogaine is an investigational psychoactive compound, not an approved treatment for cocaine-use disorder. Its therapeutic signal is scientifically interesting, but its safety margin and weak clinical evidence require caution. Calyne is an independent resource on cocaine, ibogaine, evidence, and safety. This page is information, not medical or legal advice. A clear starting point Understanding cocaine addiction and its challenges Cocaine addiction affects millions globally and can involve intense cravings, psychological dependence, and high relapse rates. It is not a simple failure of willpower; it is a substance use disorder shaped by health, environment, access to care, and changes in the brain's reward system. Craving and relapse Drug craving can remain strong after acute intoxication ends. Relapse rates for cocaine addiction may reach 60–80% within the first year, which makes sustained addiction recovery difficult and makes long-term abstinence an important but demanding goal. Limited medicines Traditional treatments commonly include cognitive-behavioral therapy, contingency management, and support groups. There are no FDA-approved medications specifically for cocaine dependence, despite the need for more effective addiction treatment options. Real health burdens Long-term drug abuse can alter reward, motivation, and impulse-control circuits. Cocaine can also strain the central nervous system and cardiovascular system; the CDC’s cocaine overdose overview describes the broader risks of cocaine use and overdose. Plant, history, pharmacology What is ibogaine and how does it work Ibogaine is a naturally occurring psychoactive alkaloid derived from the root bark of Tabernanthe iboga , a gabon plant native to Central West Africa. It is often discussed as plant medicine, but that label should not obsc

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